Polynucleotide treatment in Vienna: Innovative skin rejuvenation with salmon DNA (salmon sperm)

The polynucleotide treatment is one of the most exciting developments in aesthetic medicine: it activates the natural regeneration of your skin and rejuvenates it from the inside out. The method is also known as the “salmon sperm treatment”. At our practice in Vienna, however, you can expect not a trend, but a medically sound treatment with noticeable results.

  • Visibly fresher skin: The polynucleotide treatment specifically activates the body’s own repair processes.

  • Discreet and natural: ideal if you don’t want to do without facial expressions and individuality.

  • Versatile: Whether first wrinkles or hair loss – the polynucleotide treatment is gentle but effective.

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Polynukleotid Behandlung

Intervention duration

15 – 30 minutes

Result

1-2 months

Visible effect

8-14 months

Recommended treatments

2-3

Downtime

None / 1 day

Pain (0-10)

2-3

Sustainability

From Head of Cosmetics:

From Head of Cosmetics:

Nathalie Herndlhofer
Medically reviewed by:

Medically reviewed by:

Dr. Peter Herndlhofer

What are polynucleotides in aesthetic medicine and
what do salmon DNA & salmon sperm have to do with it?

The polynucleotide treatment uses small building blocks of DNA and RNA, our genetic material. These molecules give our skin cells natural signals for renewal. Even though the method became known in the media as the “salmon sperm treatment”, it has little to do with sensationalist journalism – but a lot to do with serious research.

The term comes from the fact that the polynucleotides used are extracted from the DNA of fish such as chum salmon or rainbow trout – specifically from their sperm cells, which are particularly rich in salmon DNA. When you read about “salmon sperm” at GoAesthetic in Vienna, you are actually talking about a highly pure, medically proven substance for gentle skin rejuvenation.

Origin and extraction of polynucleotides for skin rejuvenation: Scientific background and study situation

In our Vienna practice, we rely exclusively on sustainably sourced polynucleotides from European freshwater fish. A patented process is used to carefully remove proteins from them – this minimizes the risk of allergic reactions. However, you should not have an allergy to fish protein.

Originally developed to promote wound healing, polynucleotides have been part of medical research for decades. In the case of joint wear and tear, for example, they help to build up cartilage.

Polynucleotides have proven their worth in aesthetic medicine due to their regenerative effect on skin cells. Today we know that they have been proven to improve skin hydration and elasticity, can stimulate hair growth – and are very well tolerated, as numerous studies have consistently shown.

Mode of action of polynucleotides on the skin

Polynucleotides are not fillers, but biostimulators, because they give your tissue the impulse to regenerate. As a result, the skin begins to renew itself, leading to the following effects:

  • More moisture: Polynucleotides bind water and help the skin to retain it better – for a plump, fresh complexion.
  • Collagen build-up: The polynucleotide treatment also stimulates the fibroblasts – the skin cells that produce new collagen and elastin. This ensures more firmness and elasticity.
  • Cell protection: As antioxidants, polynucleotides neutralize free radicals, have an anti-inflammatory effect and thus prevent premature skin aging.
  • Better blood circulation: Polynucleotides promote the formation of the finest blood vessels – and thus improve the supply of oxygen and nutrients to the skin. Particularly helpful for promoting hair growth.

The result: the skin becomes more resilient, looks healthier and visibly fresher – without any artificial effects or fillers.

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Areas of application for polynucleotide treatment

The polynucleotide treatment strengthens the skin from within – making it a versatile method for anyone who wants naturally smoother skin. Although it does not replace fillers with hyaluronic acid or surgical procedures, it does provide subtle improvements in skin quality.

At our institute in Vienna, we use polynucleotide treatment (salmon DNA treatment) in the following areas:

  • Skin rejuvenation and wrinkle reduction: superficial wrinkles are reduced, the skin appears fresher and more even. The treatment can also be perfectly combined with other methods such as Profhilo, microneedling or medical peelings.
  • Eye region: Polynucleotides show their strengths particularly in fine wrinkles (crow’s feet) on the sides and below the eyes. This is because Botox is more effective in the crow’s feet area and fillers should not be injected too close to the eyelid. Polynucleotides improve the appearance of the skin.
  • Hair loss: Polynucleotides promote blood flow to the scalp and thus improve the supply of nutrients. They are particularly effective in combination with PRP treatment against hair loss, also known as autologous blood therapy. After hair transplants, they are almost a mandatory treatment in the maintenance of newly transplanted hair.
  • Scar correction: Polynucleotides support tissue regeneration – ideal for acne scars or small skin imperfections. Please note: We often recommend a combination therapy to remove acne scars.

Whether as a stand-alone therapy or in addition to other treatments – we will be happy to advise you on which combination suits your skin.

What distinguishes the polynucleotide treatment
(salmon DNA / salmon sperm) from other skin rejuvenation procedures?

In contrast to fillers or Botox treatments, polynucleotides do not change facial expressions or volume – they improve the skin structure from within. But what exactly are the differences?

  • For the wrinkle injections with hyaluronic acid volume is specifically built up to fill in sunken areas. Polynucleotides have a more subtle effect: Although they also bind moisture, they do not artificially plump up the skin – your facial features remain completely natural.
  • Botox wrinkle treatments target the muscles: They relax specific areas of the face in order to smooth expression lines. Polynucleotides, on the other hand, strengthen the collagen framework – they improve skin quality without affecting muscle activity.
  • A injection with Profhilo can best be compared to a polynucleotide treatment.

Important to know: Deep wrinkles do not disappear completely with polynucleotide treatment and the effect builds up gradually over several weeks. On the other hand, the method impresses with natural results and improved skin texture – and can be perfectly combined with treatments such as radiofrequency microneedling (Morpheus 8™) or Ultherapy®.

Your advantages with polynucleotide treatment at GoAesthetic

Natural

Polynucleotides stimulate skin renewal without building up volume – you look rejuvenated but not changed.

Compatible

Even sensitive skin benefits from the gentle effect – the purified active ingredients are considered to be particularly well tolerated.

Safe

Polynucleotides have been researched and used in medicine for decades – their effect is well documented and proven.

What is the procedure for polynucleotide injections with salmon sperm at GoAesthetic?

  • Appointment

    Simply make an appointment online or by phone. If you are unsure whether a polynucleotide treatment or another type of injection is right for you, simply make an appointment for a medical consultation.

  • Educational talk

    Before each treatment, you will have a personal consultation with the doctor. Beforehand, you will fill out an information sheet in order to obtain detailed initial information.

  • Treatment

    After thorough disinfection, we start the treatment. Several small fluid deposits are placed in the uppermost layer of the skin – it is perfectly normal to feel a slight pulling or burning sensation during the injection. After a few minutes, the complete polynucleotide treatment is already over.

  • Result

    Immediately after the treatment, you will see fine wheals (bumps on the skin), which disappear after a few minutes to hours. The following day you will see nothing more. And important: you should repeat the injection 1-2 times to get the most out of the treatment.

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Costs of a polynucleotide treatment at GoAesthetic

The cost of a polynucleotide treatment with 2ml at GoAesthetic is €390 for one region. The following regions can be selected: Eyes, face and hair, with the facial area comprising 90% of the cheek region.

  • Polynucleotide treatment eyes (2ml)
    390 €
  • Polynucleotide treatment face (2ml)
    390 €
  • Polynucleotide treatment hair (2ml)
    390 €
  • Polynucleotide treatment 2 regions (4ml)
    730 €
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Interested in polynucleotides? Simply arrange a consultation

The best way to find out whether polynucleotide treatment is suitable for you is to talk to Dr. Peter Herndlhofer in person. We take enough time for this.

The consultation is free of charge if you decide to come to us directly for treatment in Vienna. If you decide later, you will be charged a fee of €140 – €50 of which will be credited to you for each future treatment.

Polynukleotid Augenringe

What do you need to consider during polynucleotide treatment?

Before treatment:

  • Blood-thinning medication should be discontinued (please consult us or your doctor)

  • No active inflammation in the treated area (e.g. fever blisters)

  • No treatment during pregnancy and breastfeeding

After treatment:

  • Avoid intensive sport, facial massages and other cosmetic treatments for 2 days

  • No sauna, steam bath or solarium visits for a few days

  • Avoid intensive sun exposure for a few days or use sunscreen (SPF 50)

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Questions about polynucleotide treatment? Our FAQ section offers you some initial guidance.

Polynucleotides are small molecules obtained from genetic material (DNA) from fish such as salmon. They stimulate the body’s own skin renewal – for more moisture, elasticity and a naturally rejuvenated complexion.

Yes – the effect has been well researched medically and the risk of side effects is very low.

Polynucleotide therapy is suitable:

  • For first wrinkles, rough or sagging skin
  • for the treatment of scars
  • for wrinkles around the eyes
  • to stimulate hair growth

The effect sets in gradually – the first effects are usually visible after a few weeks. For optimum results, we recommend 3 treatments at intervals of 2 to 4 weeks.

Before treatment: Consult us if you are taking blood-thinning medication. No treatment during pregnancy and breastfeeding!

After the treatment: Please refrain from intensive sport, other cosmetic treatments, sauna, solarium and intensive sun exposure for a few days.

A treatment with polynucleotides at GoAesthetic costs €390 for one region. We offer the following regions: Eyes, face (mostly cheeks) and hair.

More questions? Then simply make a personal consultation appointment online.

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References

Last update: 28.05.2025

Imprint

GoAesthetic
Center for aesthetic treatments

Address:
Magdalenenstrasse 22/1
1060 Vienna

E-mail: office@goaesthetic.at

Tel: 0043 1 417 12 21

Opening hours

Monday: 08:00 – 20:00
Tuesday: 08:00 – 19:00
Wednesday: 09:00 – 19:00
Thursday: 08:00 – 19:00
Friday: 08:00 – 19:00
Saturday by appointment

Reviews

“Very nice surgery, the staff is very friendly and you feel comfortable right away! After the first treatment I already saw a great result! Can definitely recommend.”

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